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prophylaxis for migraine headaches (not effective for acute therapy) Contraindications: hepatic disease or significant dysfunction pregnancy (valproate was upgraded from Category D to Category X in 2013)(FDA Drug Safefy & Availability) Side Effects: Several epidemiologic studies have indicated a higher incidence of & an increased incidence of cardiovascular, orofacial & digital abnormalities in the offspring of mothers who took valproate during pregnancy

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In one large, prospective, observational cohort study (the Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) study), children who had been exposed to valproic acid in utero had significantly lower IQ scores at 6 years of age than those exposed in utero to lamotrigine, phenytoin, or carbamazepine monotherapy

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