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Gender differences in multiple sclerosis epidemiology and treatment response

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Resistance to osimertinib, a third-generation tyrosine kinase inhibitor targeting EGF receptor used as first-line therapy for patients with non-small cell lung cancer (NSCLC) harboring mutant EGFR, is mediated by IGF-1R signaling activated by IGF-2 in NSCLC cell lines (41)

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Given their tissue-specific expression patterns and functional pleiotropy, FABPs are positioned at the intersection of energy balance, lipid metabolism, and inflammatory signaling, and FABP dysregulation is repeatedly linked to IR and T2DM

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