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Mechanistic studies indicate that platinum/PARPi synergy is associated with sustained DNA double-strand breaks (DSBs) leading to a significantly marked increase in apoptosis [49, 50]

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Activating p53 by the antiproliferative impact of flavonoids in okra flowers resulted in the disruption of mitochondrial functions in colorectal tumor cells, ultimately restraining autophagy and apoptosis [55]

Lack of Kinin B1 receptor potentiates leptin action in the liver

In contrast, CD4 + /FOXP3 + T cells, which are regulatory T cells (Tregs), were significantly decreased in mice in the M-10 (23.4%) and M-30 (9.49%) groups but showed no significant changes in the M+D (24.5%) and DOX (28.4%) groups compared to the vehicle group (Fig

[DOI] [PubMed] [Google Scholar] 77.A double-blind, delayed-start trial of rasagiline in Parkinson's disease