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While preclinical findings are encouraging, human clinical evidence remains limited , and the compound should be viewed as a research-stage metabolic therapy rather than an established treatment for obesity or weight management

The compound also shows no inhibitory activity against nicotinamide phosphoribosyltransferase (NAMPT) or sirtuin 1 (SIRT1), key enzymes in the NAD+ salvage pathway

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Despite offering myriad of benefits, there are few side effects of vitamin b1, b6, and b12 which must be kept in mind

Malabsorption from coeliac disease, Crohns, gastric surgery or long-term metformin and proton-pump inhibitors accounts for much of the rest

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