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2,97 Studies and clinical practice of treatment of pernicious anaemia with regular high-dose injections has confirmed the safety of B12 at high dosages, and therefore neither the Institute of Medicine (IOM) in the USA nor the European Food Safety Agency (EFSA) have set an upper limit

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One much-discussed (though controversial) example of the preventive effects of antioxidants is the 'French paradox'

The trial that most convincingly raised human glutathione stores used plain oral glutathione

In some contexts it is suggested that it could support mitochondrial function or neuronal signalling, but the clinical evidence is heterogeneous and does not allow generalisation of benefits to the whole population