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Perfusion with a medium containing hypoxanthine in the presence of xanthine oxidase, which catalyzes in situ the conversion of hypoxanthine to O2 and uric acid, increased hepatic vascular resistance in isolated rat livers, which is accompanied with a decrease in BSP uptake.116 The exact mechanisms that link oxidative-stress-induced actin disorganization with tight-junctional impairment and transporter internalization are unknown, but previous studies in the literature provide some clues