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Table 2 Genomic DATA 1.5 Polygenic risk scores (PRS) As discussed in previous sections, exome sequencing provides a deeper understanding of the genetic basis of complex disorders, since it enables a global analysis not only of pathogenic variants but also of risk variants, variants of uncertain significance (VUS), and benign variants

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Moreover, SLC7A5 depletion facilitates the efficacy of the mTOR inhibitors rapamycin and everolimus in KRAS-mutant CRC tumor-bearing mice, suggesting SLC7A5 as a therapeutic strategy [81]

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