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These medications had powerful anti-inflammatory effects that extended well beyond metabolic improvement

The d-enantiomers were more strongly retained by the chiral selector than the l-enantiomers, and the LODs of the method ranged from 0.05 to 0.5 g/mL

Despite these advancement, HBOCs development is also complicated by issues such as vasoactivity caused by nitric oxide (NO) scavenging [49], nephrotoxicity from dissociated dimers [50], oxidative toxicity of hemoglobin [51], and short circulation time [52], resulting in many HBOCs varieties being discontinued or excluded from further research due to safety concerns

Pini, A., Obara, I., Battell, E., Chazot, P.L

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The needed sample size was calculated based on our previous experiments: if the difference in a parameter changes clinically significantly for at least 50 % of participants, it should show also a statistically significant difference between controls and the intervention/supplemented group