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Glutaminase: a hot spot for regulation of cancer cell metabolism

A PDX1-ATF transcriptional complex governs cell survival during stress

doi: 10.1007/s00281-019-00741-8 199 ReinckeSMvon WardenburgNHomeyerMAKornauHCSpagniGLiLYet al

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The dual agonist mechanism provides robust glycemic control and significant weight reduction, with clinical trials demonstrating A1C reductions of 1.92.4% and weight loss of approximately 1522% of body weight in non-diabetic adults with obesity (SURMOUNT-1 trial), with more modest weight loss typically observed in patients with type 2 diabetes