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To study the permeability of nanoparticles in vitro BBB models, which conform to the 3R principles with the minimalization the number of animal experiments, are widely used either in static [34] or in dynamic conditions by employing lab-on-a-chip systems [35]

Zhao, Q., Dahlin, L

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Abstract Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system that causes significant disability and healthcare burden

Similarly, zinc-finger proteins, which bind zinc ions to stabilize their structures, have been targeted with metal-based compounds like aurothiomalate, which disrupt the zinc-cysteine interactions in the proteins active site, providing a novel approach to chemotherapy and against HIV (Medici et al., 2015)