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Biomarker-based patient selection, such as circulating oxidative stress markers (e.g., MDA, 8-OHdG), remains speculative and has not been integrated into trial designs

Certain conditions like polycythemia warrant caution

Mice were housed in appropriate cages with twelve wake-light/sleep-dark cycles and an ambient temperature of 25 0.5 C

The activity of APX increased under 30 psu and decreased under hyposalinity by adding BSO

Therapeutic potential exists in targeting necroptosis markers (RIPK1, RIPK3, and MLKL) and IFN- signaling

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