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Therefore, chronic inflammation and oxidative stress are not only the core pathological mechanisms of CKD-associated sarcopenia but also promote each other to form a vicious cycle of inflammation-oxidative stress-muscle loss, which exacerbates the deterioration of CKD patients

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OPN knockout mice have less susceptibility to AILI than WT mice [114]

Lipid peroxidation is involved in calcium dependent upregulation of mitochondrial metabolism in skeletal muscle

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