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These variations highlight that the in vitro physiological response of explants is influenced by multiple factors, including genotype, species, type and concentration of PGRs, explant source, and developmental stage of explant 53,54

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FLT3 Inhibitors Are Promising Salvage Therapy for Relapsed or Refractory Acute Myeloid Leukemia (AML) in Patients with FLT3-ITD Mutations

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Furthermore, p-JNK leads to the activation of Bax and translocation to mitochondria to trigger the mitochondrial permeability transition (MPT) pore formation, along with collapsed ATP depletion and membrane potential, eventually causing DNA fragmentation and necrosis ( via upregulation of Gadd45