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3 More than 50% of Patients who Started Treatment in the Earlier Stages of AD Continued to Show Improvement in Clinical Scores After Four Years of Lecanemab Therapy The Clarity AD study included an optional tau PET substudy and used the MK6240 tracer to identify patients with low levels of tau accumulation in the brain, an indicator of early-stage AD Among these patients, after four years of lecanemab treatment, 69% of these patients showed improvement or no decline, and 56% showed improvement from baseline on the CDR-SB

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NAD + is synthesized from nicotinamide and nicotinamide riboside via two enzymatic reactions, while the pathway that yields NAD + from nicotinic acid known as the Preiss-Handler pathway includes three steps