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MYC specifically activates the expression of glutamine transporter and glutaminase in tumors, thereby regulating the reprogramming of glutamine metabolism in tumors [30, 72, 73].At the same time, MYC also regulates the expression of PD-L1 and CD47 in the tumor cells

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Increased high-temperature requirement for A serine peptidase 1 (HTRA1) levels activate NF-B protein synthesis, whereas HTRA1 knockdown downregulates NF-B protein expression