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Diacetyl-bis(4-methyl-3-thiosemicarbazonato) copperII (CuII(atsm)), an anti-ferroptotic compound that inhibits lipid radical propagation similarly to liproxstatin-1, rather than preventing iron oxidation, and is able to cross the BBB, has shown promising results in phase I PD clinical trials by improving disease severity (211)

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3.2 Predictive models for screening DILI 32% of post-approval withdrawals and 22% of clinical trial failures are caused by drug hepatotoxicity (Watkins, 2011), suggesting that preclinical studies of drugs cannot reliably assess the risk of hepatotoxicity of new medications

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