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Using the wrong syringe may: Deliver the vaccine into the wrong tissue layer Affect absorption and immune response Lead to vaccine failure For instance, intradermal vaccines require specialized syringes with fine needles for accurate delivery

Seek urgent medical attention (999 or A&E) if you experience: Jaundice : Yellowing of skin or eyes, particularly if accompanied by fever, severe abdominal pain, or confusion, indicates significant liver dysfunction requiring immediate assessment

doi: 10.1182/blood-2016-03-703439 37 EgebladMWerbZ

Conclusion We herein present a methodology for the direct modification of AONs with 5HP2Os, which are stable Michael acceptors ready to be employed for bioconjugation purposes