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Pharmacologic specificity of nicotinic receptor-mediated relaxation of muscarinic receptor precontracted human gastric clasp and sling muscle fibers within the gastroesophageal junction

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However, in addition to the pathophysiological development of critical illness caused by the effects of the primary disease, it is undeniable that extracorporeal circulation itself induces an inflammatory response, which further intensifies the systemic inflammatory response and leads to a systemic storm of inflammatory factors, further developing into the adverse outcome of multi-organ failure

Pinto et al., 2010)

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Just so inhibited by this unexplained fatigue, Thank you Rach