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Long-lasting beneficial (or at least neutral) metabolic adaptations also occur between mammalians and their different microbiota, e.g., the microbiota of the gastrointestinal tract

Reversal of this age-associated decline using the NAD + precursor nicotinamide mononucleotide (NMN) restored functional fertility, even when treatment was started at a post-reproductive age

Almeida L, Lochner M, Berod L, Sparwasser T

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These results do not apply to compounded versions of GLP-1 drugs, which are not FDA-approved and have not been evaluated for safety, effectiveness, or quality

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