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A phase II trial (Ocera Therapeutics (2014) showed a comparable efficacy to that of lactulose in patients with mHE, with fewer side effects, although more studies are required for the further development of this treatment

Targeting receptor tyrosine kinases and their signal transduction routes in head and neck cancer

Firstly, the main strength is the long study follow-up (15 months), which allows for gathering information about potential changes in patients QoL in response to long-term ALC treatment, usually not be easily detectable in studies with shorter observation periods