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In addition, novel regulators such as RNA methylation enzymes (METTL3/14) that modulate GPX4 mRNA stability (176), or RhoA-mediated vascular remodeling that enhances iron leakage into subchondral bone ( Future research should leverage high-resolution single-cell or spatial omics, functional validation in cell-specific knockout models, and joint-region-targeted delivery systems to develop more personalized and mechanistically guided ferroptosis interventions

Samarghandian S, Borji A, Farkhondeh T (2017) Attenuation of oxidative stress and inflammation by Portulaca oleracea in Streptozotocin-induced diabetic rats

McCully SP, Fabricant LJ, Kunio NR, et al

Regulating gut tryptophan metabolism could be a potential strategy for adjuvant treatment of liver cancer

ER stress, ROS generation, and ferroptosis are possibly related, but the mechanisms driving lipid peroxidation in the ER and its relationship to ferroptosis are still unclear

If you are opting for the B12 injection, it will be performed by a highly qualified, licensed professional who is under the supervision of a medical doctor