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Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimers disease

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Vigorous shaking can cause shearing forces that literally break the amino acid bonds or cause the peptide to denatureunraveling it like a ball of yarn and rendering it biologically useless

Structural features that allow oral absorption include cyclic backbone, N-methylation, D-amino acid substitution, and molecular weight under roughly 500 daltons

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