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Propionyl-CoA, the immediate precursor of D-methylmalonyl-CoA, is the breakdown product of isoleucine, valine, methionine, threonine, and thymine, as well as cholesterol and odd-chain fatty acids

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doi: 10.1016/j.ejphar.2021.174608 78 KouZDaiW

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Ideally, ECTRs in VPA intoxications should be investigated in a controlled clinical trial setting, but this is difficult to plan/perform since the overall occurrence of VPA intoxications per center will be limited to few cases