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Most nicotine in mainstream smoke is in the non-volatile, protonated form

In the U.S., the e-cigarette category alone represents a market of nearly USD 9 billion, reflecting sustained consumer demand for alternatives

of tar in cigarettes) Toxic Substances Control Act of 1976 To regulate chemical substances and mixtures which present an unreasonable risk of injury to health or the environment The term chemical substance does not include tobacco or any tobacco products Comprehensive Smoking Education Act of 1984 Requires four rotating health warning labels (all listed as Surgeon Generals Warnings) on cigarette packages and advertisements (smoking causes lung cancer, heart disease and may complicate pregnancy

Moreover, the number of included studies was relatively low which could be a reason for some non-significant associations

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