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Description

FcR-mediated functions control a broad array of antibody-driven therapeutic mechanisms, including complement-dependent cytotoxicity (CDC), antibody-dependent cell cytotoxicity (ADCC), antibody-dependent cell phagocytosis (ADCP), and the induction of cell death by apoptosis

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They also carry the risks inherent to any surgical procedure, require recovery time, and demand lifelong nutritional follow-up

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This poor oral bioavailability explains why clinical trials used subcutaneous injection

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