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While D-fructose 1,6-bisphosphate and arginine did not exhibit a significant decrease in expression in the external validation cohort, their trends aligned with the internal validation cohort

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[253] [255] however, other evidence from animal studies suggests that this reaction is catalyzed by DBH in synaptic vesicles within noradrenergic neurons in the brain

Rapidly increasing energy metabolism in vulnerable individuals can lead to adverse effects, such as mania or psychosis