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If they get two, which is less common, I think it's 2% of the population or something has two alleles, but they have a ten or elevenfold increased risk of Alzheimer's disease

MS/MS data were extracted and searched against in-house Mascot Server (Revision 2.5.0), a search engine that uses mass spectrometry data to identify and characterize proteins from sequence databases

However, neither molecular mechanisms responsible for the APE/Ref-1 gene expression induction upon oxidative injury nor functional data regarding the real in vivo role played by post-translational modifications in controlling APE/Ref-1 functional activities are clear.24 Understanding the possible relationships existing between APE/Ref-1 levels and oxidative-stress-based human liver pathologies is of enormous importance, not only for the comprehension of the role and mechanism that APE/Ref-1 may play in the initiation and development of these pathologies but also for developing diagnostic markers and therapeutic tools

10.1016/S0014-5793(99)01768-8 96 VanackerH.CarverT

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Physical activity, high-altitude acclimatization, and dietary optimization influence hemoglobin production and functional oxygen delivery