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AOD-9604: A novel lipolytic fragment of human growth hormone

NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict

5-Methyl THF serves as a methyl donor in the vitamin B 12 -dependent reactions catalyzed by methionine synthase, which remethylates homocysteine to methionine, regenerating THF

Without a concurrent reduction in caloric intake, increased circulating free fatty acids from enhanced lipolysis may simply be re-esterified and stored elsewhere

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