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Article contents Low vitamin B12 but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study Published online by Cambridge University Press: 13 December 2021 Abstract This was a longitudinal study utilising the Irish Longitudinal Study on Ageing (n 3849 aged 50 years) and investigated the relationship between blood plasma folate and B12 levels at baseline (wave 1) and incident depressive symptoms at 2 and 4 years (waves 2 and 3)

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Although body stores of vitamin B12 are sufficient to last for 25 years, vitamin B12 deficiency is common