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ADAMTS5 in osteoarthritis: biological functions, regulatory network, and potential targeting therapies

The most important serious side effects include acute pancreatitis (severe persistent abdominal pain radiating to the back, though clinical trials found similar pancreatitis rates to comparators), severe dehydration from persistent vomiting or diarrhea (signs include dizziness, decreased urination, extreme thirst), gallbladder disease including cholecystitis or cholelithiasis (right upper quadrant pain, fever, jaundice), severe allergic reactions (difficulty breathing, swelling of face or throat), and severe hypoglycemia when combined with insulin or sulfonylureas (confusion, loss of consciousness, seizures)

Given that their high toxicity may provoke serious side effects, researchers are proposing different ways to reduce their toxicity without decreasing their efficacy

Hum Exp Toxicol, 11(6): 466-472

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10.1172/JCI5909 J