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Moreover, in vivo transcellular extrusion of mitochondria from retinal ganglion cells for degradation by neighboring cells is reminiscent of exopher-like biology, and transcellular extrusion and degradation is increased in AD-model mouse brain 62 and has been reported in human neurodegenerative disease brain

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Moreover, some previous studies have shown that proximal tubular injury precedes microalbuminuria and the onset of early glomerulopathy in early DKD (6)

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